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    Home»World»COVID-19 without a vaccine: How many people would have died? Here’s a thought experiment
    World

    COVID-19 without a vaccine: How many people would have died? Here’s a thought experiment

    Justin M. LarsonBy Justin M. LarsonJune 12, 2025No Comments5 Mins Read
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    COVID-19 without a vaccine: How many people would have died? Here's a thought experiment

    Let’s time-travel for a moment—but not to a land of flying cars or robot butlers. Instead, let’s picture an alternate reality: the COVID-19 pandemic, without any vaccines. No shots, no immunity drives, no fully vaccinated stickers on social media. Just endless variants, overloaded ICUs, and a world stuck in limbo.Scary? Oh, it would’ve been terrifying.

    Year one: Déjà Vu and denial

    The virus hits. Lockdowns begin. People bake banana bread, make Dalgona coffee and search for toilet paper like it’s gold. Everyone’s hopeful that “normal” will return soon. But in this no-vaccine universe, the promise of a shot never materializes. There’s no Pfizer miracle or Moderna breakthrough. The wait just goes on… and on.Governments pump money into testing and contact tracing, but let’s be real—humans are social creatures, and not everyone plays by the rules. The virus continues to spread, morphing into new variants faster than you can say “flatten the curve.”

    Hospitals turn into war zones

    Remember how things were in early 2020? Now multiply that by years.With no vaccine to protect even the most vulnerable, hospitals become battlegrounds. ICUs are filled to the brim. Nurses are running on caffeine and heartbreak. Doctors are forced to make unthinkable decisions: Who gets the last ventilator? Whose life gets saved?Elective surgeries are cancelled. Cancer treatments are delayed. Pregnant women face birthing in isolated COVID wards. The ripple effect is brutal, and it’s not just COVID killing people anymore—it’s everything else the system can’t handle.

    The economy?

    Without vaccines, lockdowns become the only tool left to fight transmission. Entire industries collapse. Tourism? Ghost town. Restaurants? Bleeding money. Schools? On-again, off-again like a bad relationship.Small businesses close shops permanently. Unemployment soars. Mental health spirals. Zoom fatigue becomes a real medical condition (okay, not officially, but it should be). Parents juggle full-time jobs with full-time homeschooling. And kids? They lose precious years of real education, social skills, and childhood joy.Governments try stimulus packages, but the longer the pandemic drags on, the more the global economy limps. Developing countries, especially, are hit hard. Inequality widens. Some people can afford to stay home and get groceries delivered; others have to risk their lives daily to survive.

    Variants rule the world

    In our real timeline, vaccines helped prevent the worst-case scenario with Delta and Omicron. But in this world? Mutations go unchecked.Each wave is worse than the last. One variant is deadlier, another more contagious, a third one possibly affects kids more than adults. Every time we think, “This is the peak,” a new spike slams the world back into lockdown.Scientists scramble for therapies—monoclonal antibodies, antivirals, you name it. But without widespread immunity, the virus has the upper hand. You can treat individuals, sure, but you can’t stop mass transmission.

    Life becomes a constant trade-off

    Want to go to a concert? Too risky. Visit your parents? Depends on their age and how full the hospitals are. Dating? Let’s just say “Zoom first, maybe meet in 2027.” Weddings are still on hold, funerals are livestreamed, and holiday gatherings come with moral dilemmas.Everything becomes a personal risk assessment. Every cough sends someone into a panic spiral. Your social calendar isn’t built around fun anymore—it’s built around fear and exposure.Air travel remains restricted or totally banned in many countries. Global movement slows down. Cultural exchanges, international students, and borderless careers? Put on indefinite pause.

    The human toll

    Without vaccines, we could’ve lost tens of millions more people—young, old, rich, poor. It wouldn’t just be about health; it would be about identity, grief, and generational trauma.Healthcare workers would burn out at record speed. Entire families would be wiped out. Essential workers—from delivery drivers to sanitation staff—would keep everything running while taking the biggest risks. The “clap for heroes” moments would fade, replaced by frustration and despair.And long COVID? That silent, chronic thief of energy and brainpower would be far more common. We’d have millions of people unable to work or function at their previous level—with no end in sight.

    But wouldn’t we have reached herd immunity naturally?

    Sure, some argue that we might’ve eventually achieved herd immunity the “natural” way. But let’s break that down.For that to happen, 70–90% of the global population would need to get infected and survive. With a 1–3% mortality rate (conservative estimate), we’re talking tens of millions of deaths just to get there. And that’s before accounting for new variants resetting the clock. It’s not “natural immunity”—it’s a brutal numbers game.Plus, immunity from natural infection doesn’t always last. Without vaccines, reinfections would be common. You’d never really feel safe.

    So… why does this matter?

    Because we came dangerously close to this version of reality.Vaccines didn’t just save lives—they saved livelihoods. They helped reopen schools, revive businesses, reunite families. They gave us a path back to something resembling normal. And even though they weren’t perfect (hello, breakthrough infections), they drastically reduced hospitalizations, severe illness, and death.They bought us time. They gave scientists breathing room to study the virus and develop treatments. They allowed healthcare systems to catch up. And they reminded us that global collaboration, for all its flaws, can move mountains when the stakes are high.So next time someone downplays the vaccine effort or tosses out a conspiracy theory, remember: the alternative wasn’t some magical utopia where everyone lived happily ever after without shots.It was this—an endless cycle of grief, isolation, and survival.We didn’t get everything right in this pandemic, but the vaccine? That was one of humanity’s best comeback moves. Thank science, thank researchers, and thank your lucky stars we didn’t get stuck in the timeline without it.





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