Some supplements may support or increase the effects of GLP-1 medications. They aren’t a replacement for prescription drugs, but they may work alongside them. Always talk to a healthcare provider before adding any supplement to your routine.
Berberine is a compound found in certain plants. It may improve how your body uses sugar by turning on special chemical pathways in the body that control how your cells use energy (like sugar). Studies suggest that berberine can lower blood sugar and make the body more sensitive to insulin.
Because it works similarly to GLP-1, berberine may help make GLP-1 medications more effective. Some studies suggest three 500-milligram doses per day may work best.
Berberine has many other effects on the body and can interfere with other medications you may take. It’s important to talk to a doctor before starting berberine to check for potential interactions.
Curcumin is the active ingredient in turmeric, a common spice. It’s an antioxidant that may help reduce inflammation in the body.
Curcumin may help increase GLP-1 levels by improving gut health and reducing body-wide inflammation. A recent study found that curcumin supplements increased GLP-1 and improved how the body handles sugar in people with metabolic conditions.
The body doesn’t absorb curcumin well on its own, but pairing it with piperine (found in black pepper) or using a special formulation can help. It’s typically safe to take 500-1,000 milligrams of curcumin a day.
Resveratrol is a natural compound found in red grapes, red wine, and some berries. It may help support GLP-1 activity by improving how the body uses energy.
More studies in humans are needed to understand how resveratrol may increase GLP-1 levels, but initial studies are promising. Some research suggests it can increase the levels or effect of GLP-1 in your body and activate certain genes that regulate metabolism.
Resveratrol may be safe to use at a dosage of less than 1,000 milligrams (1 gram) per day. Check with a doctor before starting.
Probiotics are helpful bacteria that balance the gut microbiome. Some probiotic strains may increase GLP-1 levels, improve digestion, and support healthy blood sugar levels.
A review of several studies found that some probiotics boosted GLP-1 activity and helped with metabolism, although researchers haven’t identified a single strain that may be most effective.
The benefits may depend on your individual gut health, but probiotics are considered safe for most people.
Omega-3 fatty acids, found in fish oil, can reduce inflammation and may support GLP-1 release. One study found that people who took omega-3 supplements had higher GLP-1 levels and better insulin sensitivity.
Omega-3 supplements are usually safe, but they can increase the risk of bleeding if you take blood thinners. A typical daily dose is about 1,000 milligrams of fish oil, which may contain about 300 milligrams of omega-3s.
